微囊藻毒素LR诱导大鼠肾NRK细胞Bax蛋白表达
BAX EXPRESSION OF RAT NEPHROCYTE NRK INDUCED BY MICROCYSTION-LR
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摘要: 近年来水体富营养化已成为一个全球性关注的问题,过量的氮、磷使藻类过度生长并产生水华。微囊藻毒素是蓝藻的一些属产生的次生代谢产物,在发生水华的水体中这类毒素普遍存在。微囊藻毒素产生的原因和作用目前还不是很清楚,然而它们对动物和人类都能产生极为严重的影响。
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Keywords:
- Apoptosis /
- Microcystin /
- Bax
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[1] Zhang Z Y, Yu X Z, Wei G R, et al.Study On the whole and cells level distribution of Microcystin LR in mice[J].J.Health Toxicology,2002, 16(1):5-8[张占英,俞顺章,卫国荣,等,微囊藻毒素LR在动物体内整体水平及细胞水平的分布.卫生毒理学杂志,2002,16(1)5-8][2] Sambrook J,Frisch E E Maniatis T.Molecular cloning:a laboratory manual.2nd ed[M].Beijing:Science press,1992[3] Reed J C, Jurgensmeier J M, Matsuyama S Bcl-2 family proteins and mitochondrial[J].Biochem.Biophys.Acta,1998,1366:127-137[4] Wolter K G, Hsu Y T,Smith C L,et al.Movement of Bax from the cytosol to mitochondria during apoptosis [J].J.Cell Biol.,1997, 139(5):1281-1292[5] Fu W Y,Li M W, Chen J P et al.Detecerion of apoptosis of renal cells of mice induced by microcystin-LR[J].Acta Hydrobiologica Sinica.2004,28(1):101-102.[傅文宇,李敏伟,陈加平等,用流式细胞仪 Pl/AnnexinV双染色法检测微囊藻毒素LR诱导的大鼠肾细胞凋亡.水生生物学报2004,28(1):101-102] Zhang Z Y, Yu X Z, Wei G R, et al.Study On the whole and cells level distribution of Microcystin LR in mice[J].J.Health Toxicology,2002, 16(1):5-8[张占英,俞顺章,卫国荣,等,微囊藻毒素LR在动物体内整体水平及细胞水平的分布.卫生毒理学杂志,2002,16(1)5-8][2] Sambrook J,Frisch E E Maniatis T.Molecular cloning:a laboratory manual.2nd ed[M].Beijing:Science press,1992[3] Reed J C, Jurgensmeier J M, Matsuyama S Bcl-2 family proteins and mitochondrial[J].Biochem.Biophys.Acta,1998,1366:127-137[4] Wolter K G, Hsu Y T,Smith C L,et al.Movement of Bax from the cytosol to mitochondria during apoptosis [J].J.Cell Biol.,1997, 139(5):1281-1292[5] Fu W Y,Li M W, Chen J P et al.Detecerion of apoptosis of renal cells of mice induced by microcystin-LR[J].Acta Hydrobiologica Sinica.2004,28(1):101-102.[傅文宇,李敏伟,陈加平等,用流式细胞仪 Pl/AnnexinV双染色法检测微囊藻毒素LR诱导的大鼠肾细胞凋亡.水生生物学报2004,28(1):101-102]
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