Abstract: Studies carried out on the selection of species and strains, adjustment ofculture medium and produchtivity and quality control of products in outdoor large-scalecultivation of Spirulina spp. in Wuhan (31?N, 113癊; 2000m2 ), Shantou (EasternGuangdong, 24?N, 116?E, 20,000m2), and Zhanjiang (Western GUangdong, 21.4癗,110.7?E; 20,000m2 ). Spirulina manxima FACHB 438 was found with good adaptabilitywith stable biomass. S. platensis FACHB 439 had relahvely lower yield than that Smaxima FACHB 438 in Wuhan and Zhanjiang. In lower temperature season(December-March), S. platensis HB 83 still exhibited some adaptability and maintaineda certain biomass of yield. There was no obvious difference in the quality offoirulina products from the three areas. It is suggested that it is an efficient procedureto use different Spirulina strains in different areas or seasons for continuous cultureand stable productivity.