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罗晓春, 李安兴, 谢明权. 斜带石斑鱼黏膜免疫系统结构的研究[J]. 水生生物学报, 2005, 29(2): 198-193.
引用本文: 罗晓春, 李安兴, 谢明权. 斜带石斑鱼黏膜免疫系统结构的研究[J]. 水生生物学报, 2005, 29(2): 198-193.
LUO Xiao-Chun, LI An-Xing, XIE Ming-Quan. STUDIES ON THE MORPHOLOGY OF GROUPER (EPINEPHELUS COIOIDES) MUCOSAL IMMUNE SYSTEM[J]. ACTA HYDROBIOLOGICA SINICA, 2005, 29(2): 198-193.
Citation: LUO Xiao-Chun, LI An-Xing, XIE Ming-Quan. STUDIES ON THE MORPHOLOGY OF GROUPER (EPINEPHELUS COIOIDES) MUCOSAL IMMUNE SYSTEM[J]. ACTA HYDROBIOLOGICA SINICA, 2005, 29(2): 198-193.

斜带石斑鱼黏膜免疫系统结构的研究

STUDIES ON THE MORPHOLOGY OF GROUPER (EPINEPHELUS COIOIDES) MUCOSAL IMMUNE SYSTEM

  • 摘要: 对斜带石斑鱼皮肤、眼角膜、鳃、前肠及后肠等黏膜相关免疫组织结构进行了研究。通过组织切片的HE染色及透射电镜的观察,描述了黏膜组织的显微结构、主要免疫相关细胞在黏膜组织中的分布情况及各免疫细胞的超微结构。结果表明黏膜组织中存在杯状细胞、淋巴细胞、巨嗜细胞、单核细胞、嗜曙红细胞、嗜中性粒细胞等免疫相关细胞,具有在黏膜局部独立完成免疫应答的细胞基础。另外,还观察到了皮肤表皮对异物的吞噬过程。本文还就黏膜免疫组织的非特异和特异性免疫应答,以及黏膜免疫是否独立于系统免疫等问题进行了讨论。

     

    Abstract: Recent studies have shown fish mucosal immune system plays an important role in disease defense. In the present study,we examined the morphology of groupers (Epinephelus coioides) mucosal-associated immune tissues including skin,eye’s corn,gill,foregut and hindgut. The microstructures of these tissues were observed on the tissue sections using H-E staining,and the ultrastructures of immune cells were described using transmission electron microscopic technology. The results show several kinds of immune cells existing in mucosal-associated tissues including goblet cells,lymphocytes,macrophages,monocytes,eosinophils and nertrophils. There are many Goblet cells in skin epidermis,gill epithelial layer and lamina epithelialis,where they secret mucus to construct the first body defense line to pathogens intrusion. Lymphocytes are abundant in lamina propria of hindgut and gill sinusoids,and also observed in foregut lamina propria,basal layer of skin epidermis and between epidermis and dermis of skin. Lymphocyte’s distribution in mucosal tissues indicates mucus antibody may be mainly secreted by local ASCs (Antibody secreting cells). Phage cells and granules distribute similarly as lymphocytes and function as non-specific immune cells and antigen presenting cells in local mucosal sites. Immune cells haven't been observed in grouper eye’s corn. Density of immune cells in the gill sinusoids is significant higher than in peripheral blood. A series of interesting figures showing skin epithelia enveloping a substance has been described and speculated to a process of epithelia engulfing an exogenic substance. Antigen uptake and presentation of mucusal-associated immune tissue has been discussed. Immune cells distributed in mucosal tissues supply cell foundation for mucosal immune system to finish immune response independent of the systematic immune system. The non-specific and specific immune response of mucosal immune system,and whether the mucosal immune system is independent from the systematic immune system have also been discussed in this paper.

     

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