Abstract: This paper describes the histopathological changes in the tissues of rare minnow(Goblocypris rarus)with hemorrhage caused by artificial infection of hemorrhagicvirus of grass carp(GCHV).Extravasation,microthrombi and erythrocyte infiltration in the myofiber appeared in the muscular system of the diseased fish.In the gill,the hyperplasia and hypertrophy of branchial epithelial cell led to the fusionof the secondary lamellae, the extravasation and rupture of erythrocyte result theformation of thrombi and blood bubble. The intestinal epithelial droped and eryth-rocyte scatterred all over the mucous membrane and intestinal intima. The hepaticcell hypertrophy,hepatic parenchyma bubbling and enlargement among the gap ofhepatic cells were found in the liver section of the diseased fish. Yellow-brownishnods increased in the spleen section. The results above indicate that the histopatho-logical change is the results of GCHV infection, and rare minnow is sensitive to GCHV.