微囊藻毒素对鱼类毒性影响的研究进展

金丽娜, 徐小清

金丽娜, 徐小清. 微囊藻毒素对鱼类毒性影响的研究进展[J]. 水生生物学报, 2003, 27(6): 644-647.
引用本文: 金丽娜, 徐小清. 微囊藻毒素对鱼类毒性影响的研究进展[J]. 水生生物学报, 2003, 27(6): 644-647.
JIN Li-Na, XU Xiao-Qing. A REVIEW OF THE TOXIC EFFECT OF MICROCYSTIN ON FISH[J]. ACTA HYDROBIOLOGICA SINICA, 2003, 27(6): 644-647.
Citation: JIN Li-Na, XU Xiao-Qing. A REVIEW OF THE TOXIC EFFECT OF MICROCYSTIN ON FISH[J]. ACTA HYDROBIOLOGICA SINICA, 2003, 27(6): 644-647.

微囊藻毒素对鱼类毒性影响的研究进展

基金项目: 

国家科技招标课题滇池蓝藻水华污染控制技术研究(K99-05-35-01-01)资助

A REVIEW OF THE TOXIC EFFECT OF MICROCYSTIN ON FISH

  • 摘要: 微囊藻毒素 (Microcystins,简称MC)是一些有毒蓝藻,如微囊藻、颤藻和鱼腥藻等,产生的一种具有肝毒性的环状七肽。
  • [1] Francis G.Poisonous Australia lake [J].Nature,1878,18:11-12[2] Kenneth M, Mackenthun,Herman E F. A heavy mortality of fishes resulted from the decomposition of algae in the Yahava River, Wisconsin[J].Transactions of the American Fisheries Society,1945,75:175-180[3] Malyarevskaya Aya. Influence of anthropogenic eutrophication:effects on fish in the form of blue-green algae mass development [J].Archiv fur Hydrobiologie,1983,97(4):417-424[4] Chen S L,Liu X F, Hu C L, et al. On the digestion and utilization of Microcystis by fingerlings of silver carp and bighead [J].Acta Hydrobiologica Sinica,1990,14(1):49-59[陈少莲、刘肖芳、胡传林,等,论鲢、鳙对微囊藻的消化利用.水生生物学报,1990,14(1):49-59][5] Leeuwangh P,Kappers F I,Dekker M.Toxicity of Cyanobacteria in Dutch Lakes and Reservoirs [J].Aquatic Toxicology,1983,4(1):63-72[6] Phillips M J,Roberts R J, Stewart J A. The toxicity of the cyanobacterium Microcystis aeruginosa to rainbow trout,Salmo gairdneri[J].Journal of Fish Diseases,1985,8:339-344[7] Jin L N, Zhang W H, Zheng L, et al.Biodegradation of microcystin in Dianchi Lake aquatic environment [J].China Environmental Science,2002,22(2):189-192[金丽娜、张维昊、郑利,等,滇池水环境中微囊藻毒素的生物降解[J].中国环境科学,2002,22(2):189-192][8] Zhang W H, Fang T,Xu X Q.Study on photodegradation of cyanobacterial toxin in blooms of Dianchi Lake [J].china Environmental Science,2001,21(1):1-3[张维昊、方涛、徐小清.滇池水华蓝藻中藻毒素光降解的研究[J].中国环境科学,2001,21(1):1-3][9] Pouria S,Andrade A,Barbosa J,et al. Fatal microcystin intoxication in haemodialysis unit in Caruaru.Brazil[J].The Lancet, 1998,352:21-26[10] Persson P E,Sivonen K,Keto J, et al.Potentially toxic blue-green algae (cyanobacteria) in Finnish natural waters [J].Aqua Fennica,1984,14:147-154[11] Northcott M E,Beveridge M C M,Ross L G. A laboratary investigation of the filtration and ingestion rates of the tilapia Oreochromis niloticus, feeding on two species of blue-green algae [J].Envir.Biol.Fishes,1991,31:75-85[12] Dewan S,Wahab M A,Beveridge M C M, et al.Food selection, electivity and dietary overlap among planktivorous Chinese and Indian major carp fry and fingerlings grown in extensively managed,rain-fde ponds in Bangladesh.Aquacult[J].Fish Management,1991,22:277-294[13] Keshavanath P,Beveridge M C M,Baird D J, et al. The functional grazing response of a phytoplanktivorous fish Oreochromis niloticus to mixtures of toxic and non-toxic strains of the cyanobacterium Microcystis aeruginosa [J].J.Fish.Biol,1994,45:123-129[14] Carbris C R, Rawlin G T,Grant P, et al. A study of feral carp, Cyprinus carpio L., exposed to Microcystis aeruginosa at Lake Mokoan, Australia, and possible implications for fish health [J].Journal of Fish Diseases,1997,20:81-91[15] Beattie K A, Kaya K, Sano T, et al.Three dehydrobutyrine (Dhb)-containing microcystins from the cyanobacteriun Nostoc sp [J].Phytochemistry,1998,47(7),1289-1292[16] Dahlem A M.Structure /toxicity relationships and fate of low molecular weight peptide toxins from cyanobacteria[D],Ph.D.Thesis,University of Illinois,1989,135-148[17] Botes D P,Viljoen C C,Kruger H, et al.Configuration assignments of the amino acid residues and the presence of N-methyldehydroalanine in toxins from the blue-green alga,Microcystis aeruginosa[J].Toxicon,1982,20:1037-1042[18] Watanabe M F,Oishi S, Harada K, et al.Toxins contained in Microcystis species of cyanobacteria (blue-green algae)[J].Toxicon,1988,26:1017-1025[19] Stotts R R,Namikoshi M, Haschek W M, et al. Structural modifications imparting reduced toxicity in Microcystins from Microcystis Spp [J].Toxicon,1993,31:783-789[20] Baganz M,Staaks G,Steinberg C.Impact of the cyanobacteria toxin,microcystin-LR on behaviour of zebrafish, Danio rerio [J].Wat .Res.,1998,32(3):948-952[21] Rbergh C M I,Bylund G,Ericksson J E.Histopathological effects of microcystin-LR,a cyclic peptide toxin from the cyanobacterium (blue-green)Microcystis aeruginosa, on common carp (Cyprinus carpio L.)[J].Aquatic Toxicology,1991,20:131-146[22] Carbis C R,Rawlin G T,Mitchell G F,et al.The histopathology of carp,Cyprinus carpioL., exposed to microcystins by gavage,immersion and intraperitoneal adminidtration[J].Journal of Fish Diseases,1996,19:199-207[23] Andersen R J,Luu H A,Chen D Z X,et al.Chemical and biological evidence links microcystins to salmon"netpen liver disease"[J].Toxicon,1993,31(10):1315-1323[24] Francesca G T,Daniel R D,Christian S.Toxicity of Microcystis aeruginosa peptide toxin to yealing rainbow trout (Oncorhynchus mykiss)[J].Aquatic Toxicology,1994,30:215-224[25] Garcia B O.Toxicity of the cyanobacterium,Microcystis aeruginosa atrain 7820 to trout and tilapia:a clinical and histopathological study [D].M.Sc. Thesis,University of Stirling, Stirling,1989[26] Lock R A C,Balm P H M,Wendelaar B S E.Adaptation of fresh water fish to toxicants:stress mechanisms indused by branchial malfunction [M].Sublethal and chronic effects of pollutants on freshwater fish, edited by Muller R. Lloyd R.Fishing.Oxford: News Books.1994.124-134[27] Zhou B S,Xu L H, Zhang Y Y,et al. The effect of microcystin-LR on the liver ultrastructure of grass trap,ctenopharyngodon idellus[J].Acta Hydrobiologica Sinica,1998,22(1):90-92[周炳升,徐立红,张甬元,等,微囊藻毒素LR对草鱼肝脏超微结构影响的研究.水生生物学报,1998,22(1):90-92][28] Oberemm A,Fastner J,Steinberg C E W.Effects of microcystin-LR and cyanobacterial crude extracts on embryo-larval development of zebrafish (Danio Rerio)[J].Wat. Res.,1997,31(11):2918-2921[29] Wiegand C,Pflugmacher S,Oberemm A,et al.Uptake and effects of microcystin-LR on detoxication enzymes of early life stages of the zebra fish (Danio rerio) [J].Environmental Toxicology,1999,14(1):89-95[30] Vajcova V, Navratil S,Palikova M, et al. The effect of intraperitoneally applied pure mycrocystin LR on haematological and morphological indices of silver carp (Hypophthalmichthys molitrix Val.)[J].Acta Veterinaria (Brno),1998,67(4):281-287[31] Palikova M,Kovaru F,Navratil S, et al. The effect of pure mycrocystin LR and biomass of blue-green algae on selected immunological indices of carp (Cyprinus carpio L.)and silver carp (Hypophthalmichthys molitrix,Val.)[J].Acta Veterinaria(Brno),1998,67(4):265-272[32] Xu L H,Chen G S,Chen J P, et al. Toxic effects of microcystin on fish liver [J].Acta Hydrobiologica Sinica,1998,22(4):378-379[徐立红,陈国胜,陈加平,等,微囊藻毒素对鱼肝的毒性效应.水生生物学报,1998,22(4):378-379][33] Carmichael W W.The toxins of cyanobacteria [J].Scientific American,1994,270(1):78-86[34] Zambrano F,Canelo E.Effects of microcystin-LR on the partial reactions of the Na super (+)-K super(+)pump of the gill of carp (Cyprinus carpio Linneo)[J].Toxicon, 1996,34(4):451-458[35] Aida Infante,Wendula Riecha. The effects of cyanophyta upon zooplankton in a eutrophic tropical lake [J].Hydrobiologia,1984,113(29):293-298

    Francis G.Poisonous Australia lake [J].Nature,1878,18:11-12[2] Kenneth M, Mackenthun,Herman E F. A heavy mortality of fishes resulted from the decomposition of algae in the Yahava River, Wisconsin[J].Transactions of the American Fisheries Society,1945,75:175-180[3] Malyarevskaya Aya. Influence of anthropogenic eutrophication:effects on fish in the form of blue-green algae mass development [J].Archiv fur Hydrobiologie,1983,97(4):417-424[4] Chen S L,Liu X F, Hu C L, et al. On the digestion and utilization of Microcystis by fingerlings of silver carp and bighead [J].Acta Hydrobiologica Sinica,1990,14(1):49-59[陈少莲、刘肖芳、胡传林,等,论鲢、鳙对微囊藻的消化利用.水生生物学报,1990,14(1):49-59][5] Leeuwangh P,Kappers F I,Dekker M.Toxicity of Cyanobacteria in Dutch Lakes and Reservoirs [J].Aquatic Toxicology,1983,4(1):63-72[6] Phillips M J,Roberts R J, Stewart J A. The toxicity of the cyanobacterium Microcystis aeruginosa to rainbow trout,Salmo gairdneri[J].Journal of Fish Diseases,1985,8:339-344[7] Jin L N, Zhang W H, Zheng L, et al.Biodegradation of microcystin in Dianchi Lake aquatic environment [J].China Environmental Science,2002,22(2):189-192[金丽娜、张维昊、郑利,等,滇池水环境中微囊藻毒素的生物降解[J].中国环境科学,2002,22(2):189-192][8] Zhang W H, Fang T,Xu X Q.Study on photodegradation of cyanobacterial toxin in blooms of Dianchi Lake [J].china Environmental Science,2001,21(1):1-3[张维昊、方涛、徐小清.滇池水华蓝藻中藻毒素光降解的研究[J].中国环境科学,2001,21(1):1-3][9] Pouria S,Andrade A,Barbosa J,et al. Fatal microcystin intoxication in haemodialysis unit in Caruaru.Brazil[J].The Lancet, 1998,352:21-26[10] Persson P E,Sivonen K,Keto J, et al.Potentially toxic blue-green algae (cyanobacteria) in Finnish natural waters [J].Aqua Fennica,1984,14:147-154[11] Northcott M E,Beveridge M C M,Ross L G. A laboratary investigation of the filtration and ingestion rates of the tilapia Oreochromis niloticus, feeding on two species of blue-green algae [J].Envir.Biol.Fishes,1991,31:75-85[12] Dewan S,Wahab M A,Beveridge M C M, et al.Food selection, electivity and dietary overlap among planktivorous Chinese and Indian major carp fry and fingerlings grown in extensively managed,rain-fde ponds in Bangladesh.Aquacult[J].Fish Management,1991,22:277-294[13] Keshavanath P,Beveridge M C M,Baird D J, et al. The functional grazing response of a phytoplanktivorous fish Oreochromis niloticus to mixtures of toxic and non-toxic strains of the cyanobacterium Microcystis aeruginosa [J].J.Fish.Biol,1994,45:123-129[14] Carbris C R, Rawlin G T,Grant P, et al. A study of feral carp, Cyprinus carpio L., exposed to Microcystis aeruginosa at Lake Mokoan, Australia, and possible implications for fish health [J].Journal of Fish Diseases,1997,20:81-91[15] Beattie K A, Kaya K, Sano T, et al.Three dehydrobutyrine (Dhb)-containing microcystins from the cyanobacteriun Nostoc sp [J].Phytochemistry,1998,47(7),1289-1292[16] Dahlem A M.Structure /toxicity relationships and fate of low molecular weight peptide toxins from cyanobacteria[D],Ph.D.Thesis,University of Illinois,1989,135-148[17] Botes D P,Viljoen C C,Kruger H, et al.Configuration assignments of the amino acid residues and the presence of N-methyldehydroalanine in toxins from the blue-green alga,Microcystis aeruginosa[J].Toxicon,1982,20:1037-1042[18] Watanabe M F,Oishi S, Harada K, et al.Toxins contained in Microcystis species of cyanobacteria (blue-green algae)[J].Toxicon,1988,26:1017-1025[19] Stotts R R,Namikoshi M, Haschek W M, et al. Structural modifications imparting reduced toxicity in Microcystins from Microcystis Spp [J].Toxicon,1993,31:783-789[20] Baganz M,Staaks G,Steinberg C.Impact of the cyanobacteria toxin,microcystin-LR on behaviour of zebrafish, Danio rerio [J].Wat .Res.,1998,32(3):948-952[21] Rbergh C M I,Bylund G,Ericksson J E.Histopathological effects of microcystin-LR,a cyclic peptide toxin from the cyanobacterium (blue-green)Microcystis aeruginosa, on common carp (Cyprinus carpio L.)[J].Aquatic Toxicology,1991,20:131-146[22] Carbis C R,Rawlin G T,Mitchell G F,et al.The histopathology of carp,Cyprinus carpioL., exposed to microcystins by gavage,immersion and intraperitoneal adminidtration[J].Journal of Fish Diseases,1996,19:199-207[23] Andersen R J,Luu H A,Chen D Z X,et al.Chemical and biological evidence links microcystins to salmon"netpen liver disease"[J].Toxicon,1993,31(10):1315-1323[24] Francesca G T,Daniel R D,Christian S.Toxicity of Microcystis aeruginosa peptide toxin to yealing rainbow trout (Oncorhynchus mykiss)[J].Aquatic Toxicology,1994,30:215-224[25] Garcia B O.Toxicity of the cyanobacterium,Microcystis aeruginosa atrain 7820 to trout and tilapia:a clinical and histopathological study [D].M.Sc. Thesis,University of Stirling, Stirling,1989[26] Lock R A C,Balm P H M,Wendelaar B S E.Adaptation of fresh water fish to toxicants:stress mechanisms indused by branchial malfunction [M].Sublethal and chronic effects of pollutants on freshwater fish, edited by Muller R. Lloyd R.Fishing.Oxford: News Books.1994.124-134[27] Zhou B S,Xu L H, Zhang Y Y,et al. The effect of microcystin-LR on the liver ultrastructure of grass trap,ctenopharyngodon idellus[J].Acta Hydrobiologica Sinica,1998,22(1):90-92[周炳升,徐立红,张甬元,等,微囊藻毒素LR对草鱼肝脏超微结构影响的研究.水生生物学报,1998,22(1):90-92][28] Oberemm A,Fastner J,Steinberg C E W.Effects of microcystin-LR and cyanobacterial crude extracts on embryo-larval development of zebrafish (Danio Rerio)[J].Wat. Res.,1997,31(11):2918-2921[29] Wiegand C,Pflugmacher S,Oberemm A,et al.Uptake and effects of microcystin-LR on detoxication enzymes of early life stages of the zebra fish (Danio rerio) [J].Environmental Toxicology,1999,14(1):89-95[30] Vajcova V, Navratil S,Palikova M, et al. The effect of intraperitoneally applied pure mycrocystin LR on haematological and morphological indices of silver carp (Hypophthalmichthys molitrix Val.)[J].Acta Veterinaria (Brno),1998,67(4):281-287[31] Palikova M,Kovaru F,Navratil S, et al. The effect of pure mycrocystin LR and biomass of blue-green algae on selected immunological indices of carp (Cyprinus carpio L.)and silver carp (Hypophthalmichthys molitrix,Val.)[J].Acta Veterinaria(Brno),1998,67(4):265-272[32] Xu L H,Chen G S,Chen J P, et al. Toxic effects of microcystin on fish liver [J].Acta Hydrobiologica Sinica,1998,22(4):378-379[徐立红,陈国胜,陈加平,等,微囊藻毒素对鱼肝的毒性效应.水生生物学报,1998,22(4):378-379][33] Carmichael W W.The toxins of cyanobacteria [J].Scientific American,1994,270(1):78-86[34] Zambrano F,Canelo E.Effects of microcystin-LR on the partial reactions of the Na super (+)-K super(+)pump of the gill of carp (Cyprinus carpio Linneo)[J].Toxicon, 1996,34(4):451-458[35] Aida Infante,Wendula Riecha. The effects of cyanophyta upon zooplankton in a eutrophic tropical lake [J].Hydrobiologia,1984,113(29):293-298

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  • 收稿日期:  2002-11-05
  • 修回日期:  2003-08-02
  • 发布日期:  2003-11-24

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