估算有机化合物在鱼体中生物富集因子的片段常数法

胡海瑛, 陶澍, 卢晓霞, 习晓环

胡海瑛, 陶澍, 卢晓霞, 习晓环. 估算有机化合物在鱼体中生物富集因子的片段常数法[J]. 水生生物学报, 2002, 26(1): 25-30.
引用本文: 胡海瑛, 陶澍, 卢晓霞, 习晓环. 估算有机化合物在鱼体中生物富集因子的片段常数法[J]. 水生生物学报, 2002, 26(1): 25-30.
HU Hai-ying, TAO Shu, LU Xiao-xia, XI Xiao-huan. PREDICTION OF BIOCONCENTRATION FACTOR OF NON-POLAR ORGANIC COMPOUNDS BY FRAGMENT CONSTANT REGRESSION[J]. ACTA HYDROBIOLOGICA SINICA, 2002, 26(1): 25-30.
Citation: HU Hai-ying, TAO Shu, LU Xiao-xia, XI Xiao-huan. PREDICTION OF BIOCONCENTRATION FACTOR OF NON-POLAR ORGANIC COMPOUNDS BY FRAGMENT CONSTANT REGRESSION[J]. ACTA HYDROBIOLOGICA SINICA, 2002, 26(1): 25-30.

估算有机化合物在鱼体中生物富集因子的片段常数法

基金项目: 

自然科学基金重点项目(49632060)

国家基金创新群体(40024101)资助

PREDICTION OF BIOCONCENTRATION FACTOR OF NON-POLAR ORGANIC COMPOUNDS BY FRAGMENT CONSTANT REGRESSION

  • 摘要: 根据脂肪烃、多卤联苯、卤代苯和稠环芳烃等80种非极性有机化合物在鱼体中生物富集因子(BCF)的实测数据,建立了有机物在鱼体中生物富集因子的片段常数法估算模型。模型包含9个片段常数和16个结构校正因子,模型可决系数为0.995,平均绝对误差为0.1836个对数单位,学生化残差呈随机分布。以调整可决系数和平均绝对误差为描述统计量,进行了类别剔除的jackknife检验,在此基础上讨论了模型的稳健性。
    Abstract: Relationship between bioconcentration factor and fragment constants was investigated. Aprediction model was developed on the basis of the observed BCF values of 80 non-polar organic compounds. The precision of the model was evaluated using adjusted coefficient of determination and studentized residuals. Jackknife tests was applied to examine the robustness of the prediction model. The coefficient of determination and the mean residual of the model was 0.995 and 0.1836, respectively.
  • [1] Koch R. Molecular connectivity index for assessing ecotoxicological behaviour of organic compounds [J]. Toxicol. Environ. Chem., 1983,6:87-96[2] 卢晓霞、陶澍、胡海瑛,等. 根据分子连接性指数估算非极性有机化合物在鱼体中的生物富集因子[J]. 环境科学,1999,20:9-12[3] Leo A J. Symposium on structure-activity correlations in studies of toxicity and bio-concentration with aquatic organisms [M]. Great Lakes Research Advisory Board, Burlington, Ontario, 1975:151[4] Hammett L. Physical organic chemistry: reaction rates, equilibria and mechanisms (2nd ed.) [M]. Newyork:McGraw-Hill, 1970[5] 朴海善,陶澍,胡海瑛. 估算有机化合物土壤吸着系数Koc的片段常数法[J]. 土壤学报,2000,37:209-216[6] Nirmalakhandan N N, Speece R E. Prediction of aqueous solubility of organic chemicals based on molecular structure [J]. Environ. Sci. Technol., 1988,22:328-338[7] Sparling J et al. The effects of degree of ortho chloro substitution on the pharmacokinetics of five hexachlorobiphenyls in the rat [J]. Chemosphere, 1980, 9:29-137[8] Shaw G R, Connell D W. Relationships between steric factors and bioconcentration of polychlorinated biphenyls (PCB's) by the sea mullet (Mugil cephalus Linnaeus) [J],Chemosphere, 1980,9:731-743[9] Oliver B G, Niimi A J. Bioconcentration factors of some balogenated organics for rainbow trout: limitations in their use for prediction of environmental residues [J]. Environ. Sci. Technol, 1985,19:842-849[10] Muir D C G. Bioconcentration of PCDD's by fish: effects of molecular structure and water chemistry [J]. Chemosphere, 1985,14:829-833[11] Karin Fox et al., Kinetics of bioconcentration and clearance of 28 polychlorinated biphenyl congeners in Zebrafish (Brachydeanio rerio) [J],Ecotox. Environ. Safety, 1994,28:9-109

    Koch R. Molecular connectivity index for assessing ecotoxicological behaviour of organic compounds [J]. Toxicol. Environ. Chem., 1983,6:87-96[2] 卢晓霞、陶澍、胡海瑛,等. 根据分子连接性指数估算非极性有机化合物在鱼体中的生物富集因子[J]. 环境科学,1999,20:9-12[3] Leo A J. Symposium on structure-activity correlations in studies of toxicity and bio-concentration with aquatic organisms [M]. Great Lakes Research Advisory Board, Burlington, Ontario, 1975:151[4] Hammett L. Physical organic chemistry: reaction rates, equilibria and mechanisms (2nd ed.) [M]. Newyork:McGraw-Hill, 1970[5] 朴海善,陶澍,胡海瑛. 估算有机化合物土壤吸着系数Koc的片段常数法[J]. 土壤学报,2000,37:209-216[6] Nirmalakhandan N N, Speece R E. Prediction of aqueous solubility of organic chemicals based on molecular structure [J]. Environ. Sci. Technol., 1988,22:328-338[7] Sparling J et al. The effects of degree of ortho chloro substitution on the pharmacokinetics of five hexachlorobiphenyls in the rat [J]. Chemosphere, 1980, 9:29-137[8] Shaw G R, Connell D W. Relationships between steric factors and bioconcentration of polychlorinated biphenyls (PCB's) by the sea mullet (Mugil cephalus Linnaeus) [J],Chemosphere, 1980,9:731-743[9] Oliver B G, Niimi A J. Bioconcentration factors of some balogenated organics for rainbow trout: limitations in their use for prediction of environmental residues [J]. Environ. Sci. Technol, 1985,19:842-849[10] Muir D C G. Bioconcentration of PCDD's by fish: effects of molecular structure and water chemistry [J]. Chemosphere, 1985,14:829-833[11] Karin Fox et al., Kinetics of bioconcentration and clearance of 28 polychlorinated biphenyl congeners in Zebrafish (Brachydeanio rerio) [J],Ecotox. Environ. Safety, 1994,28:9-109

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出版历程
  • 收稿日期:  1999-10-31
  • 修回日期:  2001-04-19
  • 发布日期:  2002-01-24

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