柱状嗜纤维菌的外膜蛋白和脂多糖及其对鳜的免疫原性
OUTER MEMBRANE PROTEIN AND LIPOPOLYSACCHARIDE OF CYTOPHAGA COLUMNARIS AND THEIR IMMUNOGENICITY TO THE MANDARIN FISH,SINIPERCA CHUATSI
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摘要: 柱状嗜纤维菌(Cytophaga columnaris Reichenbach)又名柱状屈挠杆菌(Flexibacter columnaris Leadbetter),这种细菌感染几乎所有的淡水鱼类.柱状嗜纤维菌可造成严重的鳃和皮肤病变,直至引起鱼的死亡[1].国内已经分离到多株柱状嗜纤维菌.外膜蛋白和脂多糖是构成革兰氏阴性菌表面抗原最主要的成分,它们作为重要的保护性抗原而引起重视.鳜(Sinipercachuatsi)是我国名特优养殖的重要品种之一,近年来各种病害的发生严重地影响其产量.而柱状嗜纤维菌是危害鳜的病原之一.本文旨在研究这种细菌的外膜蛋白和脂多糖的不同组分对鳜的免疫原性,找出免疫原性最强的组分,为今后的疫苗的研制提供参考.
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