Dmrt基因在水生生物中的研究进展

RESEARCH PROGRESS OF DMRT GENES IN HYDROBIONTES

  • 摘要: Dmrt(Doble-sex and Mab-3 Relatated Transcription factor)是指同果蝇Dsx基因和线虫Mab-3基因同源的基因家族,其家族成员的主要特征是所编码的多肽链中都包含一个具有DNA结合能力的保守基序-DM结构域。Dmrt基因是从无脊椎动物到脊椎动物都存在的古老基因,功能涉及性别决定与分化、许多组织和器官的形成及相关功能的维持等多方面。文章综述了近来Dmrt基因在水生生物中的研究进展;按从低等到高等的顺序,梳理了水产动物Dmrt基因的功能;分析了Dmrt1作为性别决定基因的历程;进而对Dmrt基因在水生生物的研究热点做了展望。

     

    Abstract: Dmrt is a gene family that is homologous to Doublesex in Drosophila melanogaste and Mab-3 in Caenorhabditis elegans. Dmrt genes encode a large family of transcription factors including a characteristic conservative zinc finger DNA-binding domain (i.e., DM domain). This ancient gene family has been identified in animal groups ranging from invertebrates to vertebrates. Their biological functions include sex determination and differentiation, construction of tissues and organs, and maintenance related functions. This paper reviews the recent progress of Dmrt genes in hydrobionts with theirs functions in line of evolution from invertebrates to vertebrates. We analyzed the course of sex determining gene for Dmrt genes.We further presented prospects of their future research in hydrobionts.

     

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