Abstract: Six cyanobaceria were cultured in the presence of NaCl、KNO3、(NH4)2SO4、MgSO4 and CaCl2, respectively for vacuole induction, and produced different effects. Anabaena sp. 595 was the most sensitive, vacuole could be induced by all salts tested. In contrast, no salts could induce cell vacuolization in Oscillatoria animlis 284 and Spirulina maxima 438 . While Nostoc sp. 96、Plectonema boryanum 246 and Scytonema hofmanni 248 were the relatively sensitive strains, only NaCl、KNO3、or(NH4)2SO4 revenaled the inducing effect on them. The induced vacuoles were examined by pressing the sample, and it was spherical and transparent in the scope of phase microscope.