鳗鲡出血性开口病的病理学研究
PATHOLOGY OF HAEMORRHAGIC MOUTH-OPENING DISEASE OF THE EEL, ANGUILLA JAPONICA
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摘要: 本文报告了我国发生的一种鳗鲡病毒病──鳗鲡出血性开口病的组织病理变化:肝、肾、脾脏组织出血、细胞变性,骨质内有大县白细胞浸润,肝、肾、脾脏细胞超微结构病理变化明显,肾、脾脏造血组织和外周血细胞出现核染色质边集、奇异形核,大量髓鞘样结构、自噬体和自噬溶酶体等,并可见类似凋亡细胞及调亡小体结构和邻近细胞内吞噬体增多现象。根据骨组织中白细胞浸润及器官和血液中部分细胞结构已出现异型性特征,作者认为,鳗鲡出血性开口病可能有癌变的趋势.Abstract: This paper reports the histopathological changes of haemorrhagic mouth-opening disease of the eel, Anguilla japonica in China. Hyperaemia and haemorrhage were observed in tissues of the liver, spleen and kidney of the diseased fish. Bone tissues of the diseased fish were infiltrated with leucocytes. Pathological changes were also observed in organelles of the cells in the liver, spleen and kidney. Chronmatin argination , strange necleus, myolin-sheath-like saretures, autophagosomes and autophagolysosomes were observed in blood cells of haemopoietic tissues in the spleen and kidney, of periphery blood. The apoptotic-cell and apopotic-bidt like structures,incteased phogosomes in neighbouring cells were also observed in the cells of the spleen and kidney. Based on the filtration of leucocytes in the bone tissues and the atypia of some satructures in a parts of cells, it is suggested that the haemorrhagic mouth-opening disease of the eel is tending to pathological changes of a cancer.
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