Kojima M,Hosoda H,Date Y,et al.Ghrelin is a growth-hormonereleasing acylated peptide[J].Nature,1999,402:656-660

Wajnrajch M P,Ten I S,Gertner J M,et al.Genomicorganization of the human ghrelin gene[J].J Endocrinol Genet,2000,1:231-233

Tanaka M,Hayashida Y,Iguchi T,et al.Organization of the mouse ghrelin gane and promoter:occurrence of a short noncoding firstexon[J].Endocrinology,2001,142:3697-3700

Unniappan S,Lin X,Cervini L,et al.Goldfish ghrelin:molecular characterization of the complementary deoxyribonucleic acid,partial gene structure,and evidence for its stimulatory role in food in take[J]. Endocrinology, 2002,143:4143-4146

Kaiya H,Kojima M,Hnsoda H,et al.Identification of tilapia ghrelin and its effects on growth hormone and prolactin release in the tilapia,Oreochromis mossambicus[J].Comp.Biochem.Physiol.,2003b,135:421-429

Kaiya H,Kojima M,Hosoda H,et al.Amidated fish ghrelin:purification,cDNA cloning in the Japanese eel (Anguilla japonicus) and its biological activity[J].J Endoerinol,2003a,176:415-423

Kaiya H,Kojima M,Hosoda H,et al.Peptide purification,cDNA and genomic DNA cloning,and functional characterization of ghrelin in rainbow trout (Oncorhynchus mykiss)[J].Endocrinology,2003c,144:5215-5226

Yeung C M,Chan C B,Woo N Y,et al.Seabream (Sparus macrocephalus) ghrelin:cDNA cloning,genomic organization and promoter studies[J].Endocrinol,2006,189:365-379

Parhar I S,Sato H,Sakuma Y.Ghrelin gnne in cichlid fish is modulated by sex and development[J].Biochem Biophys Res Commun,2003,305:169-175

Date Y,Kojima M,Hosoda H,et al.Ghrelin,a novel growth hormone-releasing acylated peptide,is synthesized in a distinet endocrine cell type in the gastrointestinal tracts of rats and humans[J].Endocrinology,2000,141:4255-4261

Gnanapavan S,Kola B,Bustin SA,et al.The tissue distribution of the mRNA of ghrelin and subtypes of its receptor,GHS-R,in humans[J].J.Clin.Endocrinol.Metab.,2002,87:2988-2991

Sakata I,Mori T,Kaiya H,et al.Localization of ghrelin-producing cells in the stomach of the rainbow trout (Oncorhynchas mykiss)[J].Zoolog.Sci.,2004,21:757-762

Cummings D E,Shannon M H.Roles for ghrelin in the regulation of appetite and body weight[J].Arch Surg,2003,138:389-396

van der Lely A J,Tschop M,Heiman M L,et al.Biological,physiological,pathophysiological,and pharmacological aspects of ghrelin[J].Endocr Rev,2004,25:426-457

Korbonits M,Goldstone A P,Gneorguiev M,et al.Ghrelin,a hormone with multiple functions[J].Front J Neuroendoctinol,2004,25:27-68

Yamazaki M,Nakamura K,Kobayashi H,et al.Regulational effect of ghrelin on growth hormone secretion from perifnsed rat anterior pituitary cells[J].J Neuroendocrinol,2002,14:156-162

Hashizume T,Horiuchi M,Tale N,et al.Effects of ghrelin on growth hormone secretion from cultured adenohypophysial cells in pigs[J].Domest Anim Endocrinol,2003,24:209-218

Glavaski-Joksimovic A,Jeftinija K,Scanes C G,et al.Stimulatory effect of ghrelin on isolated porcine somatotropes[J].Neuroendocrinology,2003,77:367-379

Date Y,Murakami N,Kojima M,et al.Central effects of a novel acylatod peptide,ghrelin,on growth hormone release in rats[J].Biochem Biophys Res Commun,200Oh,275:477-480

Kamegai J,Tamura H,Shimizu T,et al.Regulation of the ghrelin gene:growth hormone-releasing hormone upregulates ghrelin mRNA in the pituitary[J]. Endocrinology,2001,142:4154-4157

Riley L G.,Hirano T,Grau E G.Rat ghrelin stimulates growth hormone and prolactin release in the tilapia (Oreochromis mossambicus)[J].Zool Sci,2002,19:797-800

Unniappan S,Canosa L F,Peter R E.Orexigenic actions of ghrelin in goldfish (Carassius auratus):feeding-induced changes in brain and gut mRNA expression and serum levels,and responses to central and peripheral injections[J].Neuroendocrinology,2004,79:100-108

Malagon M M,Luque R M,Ruiz-Guerrero E,et al.Intracellular signaling mechanisms mediating ghrelin stimulated growth hormone release in somatotropes[J].Endocrinology,2003,144:5372-5380

Chang J P,Johnson J D,Van Goor F,et al.Signal transduction mechanisms mediating secretion in goldfish gnnadotropes and somatotropes[J].Biochem.Cell Biol.,2000,78:139-153

Fernandez-Fernandez R,Tena-Sempere M,Aguilar E,et al.Ghrelin effects on gonadotropin secretion in male and female rats[J].Neurosci Lett,2004,362:103-107

Furuta M,Funabashi T,Kimura F.Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomizod rats[J]. Biochem.Biophys. Res.Commun.,2001,288:780-785

Unniappan 5,Peter R E.In vitro and in vivo effects of ghrelin on luteinizing hormone and growth hormone release in goldfish (Carassius auratus)[J].Am J Physiol Regul Integr Comp Physiol,2004,286:1093-1101

Yaron Z,Gur G,Melamed P,et al.Regulation of fish luteinizing hormones[J]. Int.Rev.Cyt.,2003,225:131-185

Cummings D E.,Purnell J Q,Frayo R S,et al.A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans[J].Diabetes,2001,50:1714-1719

Nakazato M,Murakami N,Date Y,et al.A role for ghrelin in the central regulation of feeding[J].Nature,2001,409:194-198

Volkoff H,Peter R E.Interactions between orexin A,NPY and galanin in the control of food intake of the goldfish,Carassias aututus[J].Regul.Pept.,2001,101:59-72

Chan C B,Cheng C H.Identification and functional characterization of two alternatively spliced growth hormone secretagogue receptor transcripts from the pituitary of black seabream,Acanthopagrus schlegeli[J].Mol.Cell.Endocrinol.,2004,214:81-95

Kozaka T,Fujii Y,Ando M,et al.Central effects of various ligands on drinking behavior in eels acclimated to seawater[J].J.Exp.Biol.,2003,206:687-692

Unniappan S,Peter R E.Structure,distribution and physiological functions of ghrelin in fish[J].Comparative Biocemistry and Physiology,Part A,2005,140:396-508