Abstract: This experiment was conducted to determine the effects of starvation on growth, proximate composition and the biochemical index of plasma of Pacific Salmon (Oncorhynchus spp.). 90 Pacific Salmon with an average weight about 217g were randomly stocked in five-test aquarium (0.25m3), which was starvation from 0 to 32d. The rearing water temperature was 17.0±2.9 . 18 fish (six fish from each triplicate aquarium) ℃ were sampled at 0, 8, 16, 24 and 32d of each starvation group, respectively. The experiment indicated that no mortality or physical abnormal sign was observed in any test group throughout the experiment. Starvation for 32d, the weight was decreased by 7.50% and the relative loss rate of weight was 0.175% on average. At the same time, the relative loss rate of weight and the starvation time had the positive correlation (P 0.05). The cholesterol (CH), triglyceride (TG) and high-density lipoprotein (HDL) had significant difference among the groups (P < 0.05) and it improved that the metabolic of lipid was active. Pacific salmon had the definitive ability of tolerating starvation relatively better for using the lipid storied in body.