CONSERVATIVE AND EVOLUTION OF TLR4'S GENE STRUCTURE AND FUNCTION IN FISH AND MAMMALIAN

Innate immunity is the first defense of organisms, which exist in all kinds of multicellular organism. Toll-like receptors (TLRs) is aclass of Pattern recognition receptors (PRRs) that involved in the recognition of pathogen-associated molecular patterns (PAMPs) and played an important role in innate immunity. In regard to TLR4, which is a member of TLRs and could recognize the lipopolysaccharide (LPS) in bacterial. In the study, the found history of TLR4, structural features of TLR4 in mammalians and fish, distribution of TLR4, difference of TLR4 in mammalians and fish, signaling transmission, and the evolution of TLR4 were reviewed. This summary in the study would provide a reference for the research of TLR.