Volume 27 Issue 3
Feb.  2014
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AI Xiao-Hui, CHEN Zheng-Wang, ZHANG Chun-Guang, WEN Hua, LIU Chang-Zheng. STUDIES ON PHARMACOKINETICS AND TISSUE CONCENTRATION OF OLAQUINDOX IN COMMON CARPS[J]. ACTA HYDROBIOLOGICA SINICA, 2003, 27(3): 273-277.
Citation: AI Xiao-Hui, CHEN Zheng-Wang, ZHANG Chun-Guang, WEN Hua, LIU Chang-Zheng. STUDIES ON PHARMACOKINETICS AND TISSUE CONCENTRATION OF OLAQUINDOX IN COMMON CARPS[J]. ACTA HYDROBIOLOGICA SINICA, 2003, 27(3): 273-277.
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STUDIES ON PHARMACOKINETICS AND TISSUE CONCENTRATION OF OLAQUINDOX IN COMMON CARPS

  • Changjiang Fisheries Research Institute, Chinese Academy of Fishery Sciences, Jingzhou, 434000;
    2. School of Life science and Technology, Huazhong university Scientist and Technology University, Wuhan, 430074

  • Received Date: November 29, 2001
  • Rev Recd Date: October 27, 2002
  • Published Date: May 24, 2003
    Graphical Abstract
    • Abstract
  • The concentration of olaquindox in the plasma and tissues of common carps was determined by high performance liquid chromatography(HPLC). Using a C18 column, the mobile phase consisted of methanol/tridistilled water (15:85). The UV detection wavelength was 372 nm. Samples were deproteined with trichloro acetic acid. The precipitated mixture was shaken and then centrifuged, the filtrate was evaporated to dryness. Within the range of 0.2-25.6 μg/mL, Olaquindox had a good linearity. The detectability was 0.04 μg/g and the average recovery of olaquindox was 85.93%-100.2%. The within day and day to day precision expressed by RSD was less than 10% at three drug levels. Pharmacokinetics parameters and residues of olaquindox were investigated in common Carps, after orally administered at a dose of 30mg/kg fish, The C T curve was in accordance with one-compartment open model with the first order absorption. The pharmacokinetic parameters of olaquindox in carps are as follows: the elimination half life(T1/2k) is 5.876h, the distribution half life(T1/2ka) is 1.466h, the peak time (Tp) is 3.913h, the peak concentration (Cmax) is 30.25ug/mL and the area under the curve(AUC) is 406.92 mg/L·h. By means of the determination of contents of olaquindox in tissus, its remnant in carp musles after oral administration with a single dose and several doses and the olaquindox excreted in the prototype. The rhythms were found in the metabolism of olaquindox in muscles, liver and kindey after oral delivery in single dose and in muscles after oral delivery in several doses. The drug excreted in the prototype accounted for 6.9% of the total amount of the drug administered. The optimum drug feeding programe and drug administration ceasing period were suggested.
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    • References (1)
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    Ministry of agriculture editorial board on " A handbook of medicines for fishery" A handbook of medicines for fishery [M]. Beijing: Chinese science and technology press, 1998,195-196.[农业部"渔药手册"编撰委员会.渔药手册[M].北京: 中国科技出版社.1998,195-196][2] Geng Y, Wang K Y. Cautions should be taken in the use of olaquindox in aguaculture[J]. Reservoir Fishery.1999, 19(6):25-26.[耿毅,汪开毓.喹乙醇在水产养殖生产上应慎用.水利渔业, 1999,19(6): 25-26][3] Xia W J, Cheng Z R. MCPKP-A microcomputer programme for kinetic analysis of drugs[J]. Journal of Pharmacology of China,1988,9(2):188-192.[夏文江,成章瑞.MCPKP-药物动力学分析的一种微机程序.中国药理学报, 1988,9(2): 188-192][4] Liu C X, Sun R Y. Experimental design for appraisal of drugs and statistics foundation [M]. Beijing: Military medicine science press,1999: 107-130.[刘昌孝,孙瑞元.药物评价实验设计与统计学基础[M].北京: 军事医学科学出版社, 1999,107-130][5] Zhu Z Z, Chen Z L, Feng Q H. Studies on pharmacokinetics and tissue concentration of olaquindox in chickens[J]. Acta Veterinaria et zootechnica sinica,1993, 24(3):259-264.[朱柱振,陈杖榴,冯淇辉.喹乙醇在鸡体内的药物动力学及组织浓度研究.畜牧兽医学报,1993,24(3):259-264][6] Jiang Y P. Studies on pharmacokinetics of "olaquindox" of new additive in feed for rabbits. Livestock farming vet's magazine, 1987,3:8-9.[蒋永培.新饲料添加剂"喹乙醇"在兔体内代谢动力学研究.畜牧兽医杂志, 1987,3:8-9][7] Kaemmer, K. Studies with olaquindox. 3rd communication. blood level pattern in rats and pigs after oral ingestion[J]. Vet. Med. Rev. 1982,(1):40-58[8] Tanaka Jiro. Detailed solutions to fishery medicines translated by Liu Shiying and Yong Wenyue.[M]. Beijing: Agricultual press. 1982.[田中二良(刘世英、雍文岳译).水产药详解.北京:农业出版社,1982][9] Spierenburg T J, Van Lenthe H, de Graaf G, et al. Liquid chromatographic determination of olaquindox in medicated feeds and in contents of porcine gastrointestinal tract [J]. J Assoc off Anal Chem.1988,71(6):1106-1109[10] Lin Q H. Veterinary pharmacology[M]. Chengdu: Sichuan science and technology press, 1990:219.[林庆华.兽医药理学[M].成都:四川科学技术出版社,1990,219][11] Li M T, Guo W L, Zhong F, et al. Studies on the depletion of oxytetracycline residues on eel (Anguilla japonica) tissues [J]. Journal of fisheries of china,1997,21(1):39-43.[李美同,郭文林,仲锋.土霉素在鳗鲡组织中残留的消除规律.水产学报,1997,21(1):39-43]
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