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YANG Xian-le, LIU Zhi-zhi, Masahito YOKOYAMA. PHARMACOKINETICS OF CIPROFLOXACINUM IN CHINESE MITTEN-HANDED CRAB, ERIOCHEIR SINENSIS[J]. ACTA HYDROBIOLOGICA SINICA, 2003, 27(1): 18-22.
Citation: YANG Xian-le, LIU Zhi-zhi, Masahito YOKOYAMA. PHARMACOKINETICS OF CIPROFLOXACINUM IN CHINESE MITTEN-HANDED CRAB, ERIOCHEIR SINENSIS[J]. ACTA HYDROBIOLOGICA SINICA, 2003, 27(1): 18-22.
shu

PHARMACOKINETICS OF CIPROFLOXACINUM IN CHINESE MITTEN-HANDED CRAB, ERIOCHEIR SINENSIS

  • Key Lab of Ecology and Physiology in Aquaculture of the Ministry of Agriculture, Shanghai Fisheries University, Shanghai 200090;
    2. Fisheries Division, Japan International Research Center for Agricultural Science, Tsukuba Ibaraki, 305-8686, Japan

  • Received Date: September 07, 2001
  • Rev Recd Date: November 29, 2001
  • Published Date: January 24, 2003
    Graphical Abstract
    • Abstract
  • To study the metabolic law of Ciprofloxacinum in Chinese mitten-handed Crab,Eriocheir sinensis,its concentrations both in hemolymph and muscle were measured by using RP-HPLC after intramuscular injection at a dose of 8.17±0.56mg·kg-1and 6.25±0.85mg·kg-1 to male and female crab at the first experiment,or at a dose of 5.99±0.27mg·kg-1 and 6 05±0 32mg·kg-1at the second experiment respectively The concentration of Ciprofloxacinum in the hemolymph was the highest immediately after injection Within an hour,the blood-drug concentration dropped sharply On the other hand,the concentration in the muscle reached maximum an hour after injection and decreased gradually thereafter It was lower than 1μg·mL-1(g-1)at 120h and undetectable at 216h This finding indicated that the injected Ciprofloxacinum moved into muscles via hemolymph in the crab.The concentrations of Ciprofloxacinum in hemolymph were best described by a two-compartment open model with first-order absorption To male and female crab,the pharmacokinetic parameter,T 1/2β,was 40.34±1.48h and 22.07±0.31h respectively Also,Pharmacokinetic difference between male and female crab was observed.
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    • References (1)
  • [1]
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    Yang J. Fisheries medicine manual[M]. Beijing: Science and Technology Press of China. 1998, 179—180.[杨坚主编,渔药手册.北京:中国科学技术出版社.1998,179-180][2] Li T W, Ding M J, Song X M, et al. Preliminary studies on the mechanism of Vibrio fluvialis-Ⅱ resistance to antibiotics. Oceanologia ET Limnoligia Sinica,1996,27(6):637—645[李太武,丁明进,宋协民,等.皱纹盘鲍脓胞病病原菌--河流弧菌-Ⅱ的抗药机制的初步研究.海洋与湖沼,1996,27(6):637-645][3] Lin T R, Yu N F. The synthetical treatment for Trionyx sinensis with coexistence symptom of acute gastroenteritis and branchial inflammation[J]. Aquaculture of interior Land. 1997, 7: 25.[林天然,余乃凤.甲鱼急性肠胃炎鳃腺炎并发症的综合治疗.内陆水产,1997,7:25][4] Meng Q X, Yu K K. The diagnosis, prevention and cure for the disease of fish, shrimp, crab and shellfish[M]. Bingjing: Agriculture Press of China. 1996,255—281.[孟庆显,余开康.鱼虾蟹贝疾病诊治和防治.北京:中国农业出版社.1996,255-281][5] Yang X L, Liu Z Z, Sun W Q, et al. The method of RP-HPLC of ciprofloxacinum in hemolymph of Eriocheir sinenses[J]. Journal of Fisheries of China. 2000,25(4): 348-355.[杨先乐,刘至治,孙文钦,等.中华绒螯蟹血淋巴内盐酸环丙沙星的反相高效液相色谱法的建立.水产学报,2001,25(4):348-355][6] Cai W C, Li B Y, Li Y M. The experimental technique tutorial of Bio-chemical[M]. Shanghai: Fudan University Press. 1983: 47. [蔡武城,李碧羽,李玉民.生化实验技术教程[M].上海:复旦大学出版社.1983:47] [7] Nouws J F M,Grondel J L,Schutte A R,et al., Pharmacokinetics of ciprofloxacin in carp, African catfish and rainbow.trout[J].Vet-Quart,1988,10:2—216[8] Zhang Z X, Zhang Y B, Yang R S. The pharmacokinetic of Norfloxacin studies on common crap[J]. Journal of veterinary of China. 2000, 20(1): 66-69.[张作新,张雅斌,杨永胜.诺氟沙星在鲤鱼体内的药代动力学.中国兽医学报,2000,20(1):66-69]
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