Codd G A, Morrison L F, Metcal F J S. Cyanobacterial toxins: risk management for health protection [J]. Toxicology and Applied Pharmacology, 2005, 203: 264-272

[3] Falconer I R. An overview of problems caused by toxic blue-green algae (cyanobacterium) in drinking and recreational waters [J]. Environmental Toxicology, 1999, 14: 5-12

de Figueiredo D R, Azeiteiro U M, Esteves S M, et al. Microcystin- producing blooms-a serious global public health issue [J]. Ecotoxicology and Environmental Safety, 2004, 59: 151-163

[4] Mackintosh C, Beattie K A, Klumpp S, et al. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants [J]. FEBS Letters, 1990, 264: 187-192

[5] Weng D, Lu Y, Wei Y, et al. The role of ROS in microcystin- LR-induced hepatocyte apoptosis and liver injury in mice [J]. Toxicology, 2007, 232: 15-23

[6] Zhang B J, Li X Y. Prolong sub-chronic exposed to Microcystis cell extract results in oxidative stress in mice liver [J]. Acta Hydrobiologica Sinica, 2009, 33: 1088-1094

[7] Gehringer M M, Govender S, Shah M, et al. An investigation of the role of vitamin E in the protection of mice against microcystin microcystin toxicity [J]. Environmental Toxicology, 2003, 18: 142-148

[8] Gehringer M M, Downs K S, Downing T G, et al. An investigation into the effect of selenium supplementation on microcystin hepatotoxicity [J]. Toxicon, 2003, 41: 451-458

[9] Tinggi U. Selenium: its role as antioxidant in human health [J]. Environmental Health and Preventive Medicine, 2008, 13: 102-108

[10] L?J, Cheng J. Antiangiogenic activity of selenium in cancer chemoprevention: metabolite-specific effects [J]. Nutrition and Cancer, 2001, 40: 64-73

[11] Rayman M P. Selenium in cancer prevention: a review of the evidence and mechanism of action [J]. Proceedings of the Nutrition Society, 2005, 64: 527-542

[12] Hilton J W, Hodson P V, Slinger S J. The requirement and toxicity of selenium in rainbow trout (Salmo gairdneri) [J]. Journal of Nutrition, 1980, 110: 2527-2535

[13] Ross S A, Srinivas P R, Clifford A J, et al. New Technologies for Nutrition Research [J]. Journal of Nutrition, 2004, 134: 681-685

[14] Zhang J S, Gao X Y, Zhang L D, et al. Biological effects of a nano red elemental selenium [J]. Biofactors, 2001, 15: 27- 38

[15] Jia X, Li N, Chen J. A subchronic toxicity study of elemental Nano-Se in Sprague-Dawley rats [J]. Life Sciences, 2005, 76: 1989-2003

[16] Zhang J, Wang H, Yan X, et al. Comparison of short-term toxicity between Nano-Se and selenite in mice [J]. Life Sciences, 2005, 76: 1099-1109

[17] Huang B, Zhang J, Hou J, et al. Free radical scavenging efficiency of Nano-Se in vitro[J]. Free Radical Biology and Medicine, 2003, 35: 805-813

[18] Ichimura T. Media for blue-green algae [A]. In: Nishizaua M, Chihara M (Eds.), Methods in Algology [C]. Kyoritsu Tokyo. 1979, 294

[19] Metcalf J S, Codd G A. Microwave oven and boiling water bath extraction of hepatotoxins from cyanobacterial cells [J]. FEMS Microbiology Letters, 2000, 184: 241-246

[20] Harada K I, Suzuki M, Dahlem A M, et al. Improved method for purification of toxic peptide produced by cyanobacteria [J]. Toxicon, 1988, 26: 433-439

[21] Ding X S, Li X Y, Duan H Y, et al. Toxic effects of Microcystis cell extracts on the reproductive system of male mice [J]. Toxicon, 2006, 48: 973-979

[22] Giannopotitis C N, Ries S K. Superoxide dismutase in higher plants [J]. Plant Physiology, 1977, 59: 309-314

[23] Cakmak I, Marschner H. Magnesium deficiency and high light intensity enhance activities of superoxide dismutase, ascrobate peroxidase, and glutathione reductase in bean leaves [J]. Plant Physiology, 1992, 98: 1222-1227

[24] Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction [J]. Analytical Biochemistry, 1979, 95: 351-358

[25] Beutler E, Duron O, Kelly B M. Improved method for the determination of blood glutathione [J]. The Journal of Laboratory and Clinical Medicine, 1963, 61: 882-890

[26] Paglia D E, Valentine W N. Studies on the qualitative characterization of erythrocyte glutathione peroxidase [J]. The Journal of Laboratory and Clinical Medicine, 1967, 70: 159- 169

[27] Bradford M M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding [J]. Analytical Biochemistry, 1976, 72: 248-254

[28] Guzman R E, Solter P F. Hepatic oxidative stress following prolonged sublethal microcystin-LR exposure [J]. Toxicologic Pathology, 1999, 27: 582-588

[29] Moreno I, Pichardo S, Jos A, et al. Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally [J]. Toxicon, 2005, 45: 395-402

[30] Kumar O, Sugendran K, Vijayaraghavan R. Oxidative stress associated hepatic and renal toxicity induced by ricin in mice [J]. Toxicon, 2003, 41: 333-338

[31] Helmy M H, Ismail S S, Fayed H, et al. Effect of selenium supplementation on the activities of glutathione metabolizing enzymes in human hepatoma Hep G2 cell line [J]. Toxicology, 2000, 144: 57-61

[32] Arteel G E, Sies H. The biochemistry of selenium and the glutathione system [J]. Environmental Toxicology and Pharmacology, 2001, 10: 153-158

[33] Pflugmacher S, Wiegand C, Oberemm A, et al. Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication [J]. Biochimica et Biophysica Acta (BBA)- General Subjects, 1998, 1425: 527-533