中国林蛙皮肤丝氨酸蛋白酶抑制剂RCSPI2的基因克隆和原核表达

张曙光, 张哲文, 张丽芳, 王孝敏, 尚德静

张曙光, 张哲文, 张丽芳, 王孝敏, 尚德静. 中国林蛙皮肤丝氨酸蛋白酶抑制剂RCSPI2的基因克隆和原核表达[J]. 水生生物学报, 2010, 34(3): 629-633.
引用本文: 张曙光, 张哲文, 张丽芳, 王孝敏, 尚德静. 中国林蛙皮肤丝氨酸蛋白酶抑制剂RCSPI2的基因克隆和原核表达[J]. 水生生物学报, 2010, 34(3): 629-633.
ZHANG Shu-Guang, ZHANG Zhe-Wen, ZHANG Li-Fang, WANG Xiao-Min, SHANG De-Jing. CLONING AND PROKARYOTIC EXPRESSION OF THE SERINE PROTEASE INHIBITOR RCSPI2 FROM THE SKIN OF CHINESE BROWN FROGS, RANA CHENSINENSIS[J]. ACTA HYDROBIOLOGICA SINICA, 2010, 34(3): 629-633.
Citation: ZHANG Shu-Guang, ZHANG Zhe-Wen, ZHANG Li-Fang, WANG Xiao-Min, SHANG De-Jing. CLONING AND PROKARYOTIC EXPRESSION OF THE SERINE PROTEASE INHIBITOR RCSPI2 FROM THE SKIN OF CHINESE BROWN FROGS, RANA CHENSINENSIS[J]. ACTA HYDROBIOLOGICA SINICA, 2010, 34(3): 629-633.

中国林蛙皮肤丝氨酸蛋白酶抑制剂RCSPI2的基因克隆和原核表达

基金项目: 

辽宁省优秀人才项目(2007R27)资助

CLONING AND PROKARYOTIC EXPRESSION OF THE SERINE PROTEASE INHIBITOR RCSPI2 FROM THE SKIN OF CHINESE BROWN FROGS, RANA CHENSINENSIS

  • 摘要: 丝氨酸蛋白酶抑制剂广泛存在于动物、植物及微生物体内[1], 是一类丝氨酸蛋白酶活性调节剂, 能调节生物体内许多重要的生命过程, 如蛋白质折叠、血凝、补体激活、炎症反应、细胞迁移、细胞基质重建、以及肿瘤抑制等[2,3], 很多已被开发为新药, 在临床上有广泛应用。基于其序列、拓扑结构及功能的相似性, 能分成16 个家族[4],是一个蛋白超家族, 每个家族成员都具有相似的氨基酸顺序、保守的三级结构和独特的作用机制。
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出版历程
  • 收稿日期:  2009-07-30
  • 修回日期:  2010-01-23
  • 发布日期:  2010-05-24

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