Volume 33 Issue 1
Aug.  2014
Turn off MathJax
Article Contents
Abstract
References
LIU Yong-Tao, AI Xiao-Hui, YANG Hong. PHARMACOKINETI CS OF FLORFENICOL IN CHANNEL CATFISH (ICTALURUS PUNCTATUS) AT D IFFERENTWATER TEM PERATURES[J]. ACTA HYDROBIOLOGICA SINICA, 2009, 33(1): 1-6.
Citation: LIU Yong-Tao, AI Xiao-Hui, YANG Hong. PHARMACOKINETI CS OF FLORFENICOL IN CHANNEL CATFISH (ICTALURUS PUNCTATUS) AT D IFFERENTWATER TEM PERATURES[J]. ACTA HYDROBIOLOGICA SINICA, 2009, 33(1): 1-6.
shu

PHARMACOKINETI CS OF FLORFENICOL IN CHANNEL CATFISH (ICTALURUS PUNCTATUS) AT D IFFERENTWATER TEM PERATURES

  • Yangtze River Fisheries Research Institute,Chinese Academy of Fishery Science,Freshwater Fish Germplasm Quality Supervision andTesting Center,Ministry of Agriculture,Jingzhou 434000

  • Received Date: April 22, 2007
  • Rev Recd Date: February 15, 2008
  • Published Date: January 24, 2009
    Graphical Abstract
    • Abstract
  • The pharmacokinetics of florfenicol (FF) was investigated with a single doe of.0mg/kg body weight after oral gavage administration in channel catfish (Ictalurus punctatus) at the water temperature of 18℃ and 28℃.Florfenicol and its metabolite FlorfenicolAmine (FFA) concentrations in fish p lasma were simultaneously determined using high-perform-ance liquid chromatography (HPLC) with UV detection.Pharmacokinetic parameters were calculated by using the 3p97 Practical Pharmacokinetic Program software.The results showed that the kinetics of the drug was found to be temperature dependent.Plasma concentration-time data of florfenicol were best fitted using a one-compartmental open model at both 18℃ and 28℃ water temperature.The kinetic equation were Cp lasma=7.921 (e -0.036t-e-0.180t) and Cp lasma=9.061 (e-0.08.t-e-0.30.1t) at 18℃ and 28℃ respectively.The major pharmacokinetic parameters atwater temperature of 18℃ and 28℃ were as follows: the absorp tion half-time (T1/2kα) 3.845h and 2.301h, respectively; the elimination half-time (T1/2ke) 19.118h and 8.519h, respectively; The time point of the maximum p lasma concentration (Tp) 1.1136h and 5.953h respectively, Peak p lasma concentration (Cmax) were 4.074μg/mL and 4.226μg/mL, respectively;Area under curve (AUC) 174.547μg/mL·h and 8.1279μg/mL·h, respectively; Mean residence time (MRT) were 27.58.h and 12.290h, respectively.Relatively apparent distributed volume V/F (c) were app roached that were 1.512L/kg and 1.580L/kg respectively.Florfenicol administration for p reventing and controlling bacterial disease of channel catfish which is recommended to be once two days at 18℃ or once a day at 28℃with a doe of 10mg/kg bodyweight by oral administration.The main metablite FFA of FF was-not detected in channel catfish p lasma samp le.
    • FullText(HTML)
    • References (11)
  • [1]
    Xu L W,Liao C R,Liu G F1Security about florfenicol used in aquaculture [J]. Journal of Fishery Sciences of China, 2005, 1(4): 512-518[徐力文,廖昌容,刘广锋. 氟苯尼考用于水产 养殖的安全性. 中国水产科学, 2005, 1(4): 512-518]
    [2]
    MartinsenB, Horsberg T E,Varma K J, et al. Single dose pharma cokinetic study of florfenicol in Atlantic salmon (Salmo salar) in sea water at 11℃ [J]. Aquaculture, 1993, 112: 1
    [3]
    ZhuLM, YangXL,LinQ C, et al. The residues and pharmacoki netics of florfenicol in Trionyx sinensis following intramascular in jection and oral administration [J]. Journal of Fisheries of China, 2006,30(4): 515-519[朱丽敏,杨先乐,林启存,等. 肌肉和 口服氟苯尼考在中华鳖体内残留分析及药代动力学. 水产学 报, 2006, 30 (4): 515-519]
    [4]
    Samuelsen O B,Bergh O, Ervik A. Pharmacokineticsof florfenicol in cod Gadus morhua and in vitro antibacterial activity against Vibrio anguillarum [J]. Dis Aquat Organ, 2003, 56: 127-133
    [5]
    Horsberg T E, Hoff KA and Nordmo R. Pharmacokinetics of flor fenicol and its metabolite florfenicol amine in Atlantic salmon [J]. Journal of Aquatic Animal Health, 1996, 8: 292-301
    [6]
    BSAC. A guide to sensitivity testing. Report of the working party on antibiotic sensitivity testing of the British Society for Antimi crobial Chemotherapy [J]. J. Antim icrob. Chemother, 1991, 23: 1-47
    [7]
    Ho S P, Hsu T Y, ChenM H, et al. Antibacterial effect of chlor amphenicol, thiamphenicol and florfenicol against aquatic animal bacteria [J]. The Journal of Veterinary M edical Science, 2000, 62: 479-485
    [8]
    McGinnisA, Gaunt P, Santucci T, et al. In vitro evaluation of the susceptibility of Edwardsiella ictaluri, etiological agent of enteric septicemia in channel catfish, Ictalurus punctatus (Rafinesque), to florfenicol [J]. J Vet Diagn Invest,2003, 15: 576-579
    [9]
    Fukui H, Fujihara Y, Kano T. In vitro and in vivo antibacterial activities of florfenicol, a new fluorinated analog of thiamphenicol against fish pathogens [J]. Fish Pathology, 1987,22: 201-207
    [10]
    Zhao J, Kim EH, Kobayashi T, et al. Drug resistance ofVibrio angullarum isolated for m ayu between 1989 and 1991[J]. N ippon Suisan Gakkishi, 1992, 58: 1523-1527
    [11]
    Ai X H,Liu C Z and Zhou Y T. A study on phar macokinetic of sulphamethoxazole in grass carp at different temperatures and administration regimes [J]. Acta Hydrobiologica Sincica, 2005, 29 (2): 210-214[艾晓辉,刘长征,周运涛. 不同水温和给药方 式下磺胺甲 唑在草鱼体内的药学研究. 水生生物学报, 2005, 29(2): 210-214]
    • Related Articles

Catalog

    Get Citation
    PDF
    XML
    Article views (1078) PDF downloads (621) Cited by()
    Related

    Editorial Office of Acta Hydrobiologica Sinica

    Address：No. 7 Donghu South Road, Wuchang District, Wuhan, Hubei Province, China

    Tel：027-68780701；027-68780800 E-mail：acta@ihb.ac.cn  

    Supported byBeijing Renhe Information Technology Co. Ltd  Technical support：info@rhhz.net

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return